Idebenone and Urine Discoloration
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Idebenone and Urine Discoloration

Idebenone is prescribed for Leber’s Hereditary Optic Neuropathy as a way to manage the visual impairment associated with this hereditary disease in children and adult patients (LHON). The average dose is 800 to 1000 mg/day, administered 3 times per day. Capsules should be administered with water or juice. Idebenone can be taken with fatty based foods as food increases the bioavailability of idebenone. As the metabolites of idebenone are colored it may induce chromaturia, (a brownish/red coloration of urine). This is nothing to worry about as it is not hematuria (blood in the urine). That said, if you do have a kidney or any blood disorder you should be aware of this.

In vitro (glass test tubes) have shown that Qs10, a metabolite idebenone, does not inhibit cytochrome P450, an enzyme that purifies the blood of foreign substance.

No human studies to date have been established regarding idebenone and pregnant women however animal studies indicate that there is no harmful effect. Rat studies have shown that idebenone shows up in breast milk. Thus far no studies on human fertility have been performed.

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